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Weight loss during this initial period typically ranges from one to two pounds per week as your body adapts to the medication

10.1074/jbc.m111.229518 J

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Alteration in insulin signaling may accelerate the onset of Alzheimers disease, by changing the intracellular concentration of neurotransmitters involved in memory formation and functioning, and influencing on amyloid--related processes and amyloid clearance (Craft, 2007